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apalutamide will minimize the extent or outcome of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medication that happen to be CYP3A4 substrates may lead to lower exposure to those medicines.nevirapine will lessen the level or effe